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· Higher rates of AKI on ACEI/ARB were not reported in any of the landmark trials that demonstrated the benefits of these drugs in slowing progression of diabetic or non-diabetic kidney disease—but this could partly be due to the fact that these trials were conducted in an era before agreement on a uniform biochemical definition of AKI and Cited by:
AKI is not clear and likely involves numerous factors such as the intrinsic effect of AKI on outcomes as well as indirect effects that loss of kidney function may be associated with such as alterations in drug dosages, limitations on diagnostic testing and provision of File Size: KB.
Accordingly, it does not affect glomerular autoregulation and can be used safely in CKD and AKI. Statins. Statins do not accumulate in renal impairment, are not associated with acute kidney injury following cardiac surgery (80, 81) and may reduce the risk of contrast induced AKI (82, 83).
In contrast, for many patients, exposure to the risk of AKI associated with NSAID and selective COX-2 inhibitors is not justified by their benefits, other options being available. Insulin and oral hypoglycaemic agents in AKI. Prescribing of oral hypoglycaemic agents in renal failure has been reviewed (59).
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